The schedule is subject to change without notice.
Synthesis and Characterization of Monodisperse Nickel Nanoparticles using a Microreactor
Minoru T. MIYAHARA, Satoshi WATANABE :
Dept. Chem. Eng., Kyoto University, Kyoto, Japan
Masaaki ITO, Sumihito SAGO :
Noritake Co. Ltd., Aichi, Japan
We applied a micromixer to the flow synthesis of monodisperse nanoparticles. Hydrazine aqueous solution and aqueous solution of nickel(II) chloride and CTAB were mixed in the first micromixer, whose outlet was then mixed in the second micromixer with sodium hydroxide aqueous solution. Through intensive investigation, nickel nanoparticles were successfully synthesized with narrow size distribution. The key to the success was found to be the sub-second order of residence time AFTER the first mixer BEFORE the mixing in the second one. The micromixers with quite high mixing performance, which can attain milliseconds of mixing time, can provide this kind of fast process to assure the monodisperse nanoparticles.
Chemical and Process-Design Intensification and Use for Micro-Flow Particle Synthesis
V. HESSEL, T. NOEL, Q. WANG :
Eindhoven University of Technology, Micro Flow Chemistry and Process Technology, Eindhoven, the Netherlands
Eindhoven University of Technology, Micro Flow Chemistry and Process Technology, Eindhoven, the Netherlands
Micro process technology has given strong push to continuous chemical manufacture via facilitating heat and mass transfer; named transport intensification. Next big step was to develop tailored process chemistry in flow under highly intensified conditions. This has been coined Novel Process Windows and has two research pillars - unusual and typically harsh process conditions (chemical intensification) and, in more holistic picture, an entirely new integrated (end-to-end) process design (process-design intensification). Novel process windows also promote micro-flow particle synthesis. Most pronounced is this for the selective cascaded processing (reaction integration) of the diverse elemental steps needed to make a nanoparticle. High-temperature flow operation is a second NPW-motif. Emphasis will be on metal and polymer micro- and nanoparticles.
Morphology Control of Lithium Ion Battery Electrode with Nano Materials by using Continuous Kneading Process
Dr. Takehisa Fukui :
KURIMOTO, Ltd., Osaka, Japan
KURIMOTO, Ltd., Osaka, Japan
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Chemical Nanotechnologies: From Molecules to Functional Nanostructures for Energy and Health Applications
Sanjay MATHUR, Thomas FISCHER :
Chair of Inorganic and Materials Chemistry, Institute of Inorganic Chemistry, University of Cologne, Cologne, GERMANY
Chair of Inorganic and Materials Chemistry, Institute of Inorganic Chemistry, University of Cologne, Cologne, GERMANY
Chemical nanotechnologies have played, in the past few decades a major role in the convergence of life, physical and engineering sciences leading not only to simple collaboration among the disciplines but to a paradigm shift based on true disciplinary integration. The successful synthesis, modification and assembly of nanobuilding units such as nanocrystals and wires of different materials have demonstrated the importance of chemical influence in materials synthesis, and have generated great expectations for the future. Implications of chemistry as an innovation motor are now visible for knowledge leap forward in various sectors such as materials engineering for energy, health and security.
Nano and Fine Particles Surface Design for Aggregation and Dispersion Behavior Control in Liquid to Apply Functional Material
Hidehiro KAMIYA :
Dean, Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan
Dean, Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan
Nano and fine particles dispersion and aggregation behavior control is one of the most important fundamental processes for the application of nanoperticles to various functional devices, such as ceramics, polymer composite and electrode of Li battery, and pigment, cosmetics and pharmaceutical products.. By the optimum surface modification on nanoparticles, uniform nanoparticles dispersed polymer composites and other functional devices were prepared without particle aggregation. Based on the analysis of surface interaction and molecular level surface structure by using colloid probe AFM and other method, we are developing surface design concepts for nanoparticles dispersion behavior control.
Coupling Biorelevant Dissolution with Physiologically Based Pharmacokinetic Modelling to Predict in vivo Drug Performance After Oral Administration
Jennifer Dressman :
Goethe University, Frankfurt am Main, Germany
Goethe University, Frankfurt am Main, Germany
Testing release from drug products using Biorelevant methods is useful for
1) Choosing the best formulation to take into the clinic
2) Determining whether a new formulation is bioequivalent with its predecessor
3) Determining whether a generic product will be bioequivalent with the comparator product.
We will show how coupling the Biorelevant release data with physiologically based pharmacokinetic models can lead to accurate predictions of in vivo performance of the drug product.
Cocrystal Formation and Thermal Behaviors Based on Binary Phase Diagrams
Katsuhide Terada :
Faculty of Pharmaceutical Sciences, Toho University
Faculty of Pharmaceutical Sciences, Toho University
In this research, cocrystal screening was performed by thermal analysis. When a physical mixture of two components capable of cocrystal formation was heated using DSC, an exothermic peak associated with cocrystal formation was detected. In some combinations, several endothermic peaks were detected and associated with metastable eutectic melting, eutectic melting, and cocrystal melting. In contrast, when a physical mixture of two components incapable of cocrystal formation was heated using DSC, one endothermic peak which was associated with eutectic melting was detected. It was clarified that thermal analysis is one of method for the screening of cocrystal formation.
Novel Pharmaceutical Cocrystal Consisting of Paracetamol and Trimethylglycine, a New Promising Cocrystal Former
Toshiro FUKAMI :
Meiji Pharmaceutical University, Tokyo, Japan
Toyofumi SUZUKI, Kazuo TOMONO :
School of Pharmacy, Nihon University, Chiba, Japan
Meiji Pharmaceutical University, Tokyo, Japan
Toyofumi SUZUKI, Kazuo TOMONO :
School of Pharmacy, Nihon University, Chiba, Japan
Paracetamol (APAP), a frequently used antipyretic drug, has poor compression moldability. We conducted an exploratory screening assay to find a novel cocrystal former (coformer). Pharmaceutical ingredients approved for use in drugs, and coformers previously reported in the literature, were investigated as APAP coformers in total number of 70. As a result, we identified several novel cocrystals consisting of APAP and pharmaceutically acceptable ingredients, in particular combination with trimethylglycine (TMG) exhibited improved tabletability. In addition, taste sensing measurements suggested that TMG has a sweet and umami taste. Thus, TMG might suppress the bitterness of APAP, since TMG has been used as sweetener in food industry.
Nanomedicine for Non-invasive Drug Delivery Across Epithelial Barriers – Intestines, Skin and Lung
LORETZ Brigitta :
Helmholtz Institute for Pharmaceutical Research Saarland
Helmholtz Institute for Pharmaceutical Research Saarland
Between the intended site of action of a drug and the site of its administration to the patient, there are always some biological barriers. For non-invasive ("needle-free") administration, the body's outer epithelia - intestines, skin and lungs - are of particular importance. This presentation will highlight recent work in our attempts to develop i) improved in vitro models of cellular and non-cellular biological barriers and ii) of new drug carriers to overcome such barriers. Our particulate carriers, often in nano-size, showed advantages in anti-inflammatory colitis therapy, transfollicular vaccination and delivery of nuclease-encoding mRNA for genome editing in SP-B deficient mice.
Development of Polymeric Nanoparticle Carrier for Drug Delivery System and Design as Solid Dosage Forms
Hiromitsu YAMAMOTO :
Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, Japan
Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, Japan
We developed the emulsion solvent diffusion method for preparation of DL-lactide / glycolide copolymer (PLGA) nanoparticle as drug carrier and evaluated the several applications for the drug delivery devices, e.g. oral peptide delivery, pulmonary peptide delivery, nucleic acid delivery, antibacterial drug delivery against periodontal disease, brain targeting and so on. To improve the convenience of nanoparticle application for drug delivery, we successfully designed the formulation of the nanoparticulate drug delivery system as tablet dosage form.